Abiraterone and Spironolactone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Abiraterone and Spironolactone unless specifically directed by your doctor.
How Abiraterone interacts with Spironolactone
Spironolactone has partial androgen receptor agonist activity that may stimulate prostate cancer cell proliferation, antagonising abiraterone's androgen-deprivation effect.
What you should do
Avoid spironolactone in patients on abiraterone for prostate cancer; use eplerenone or a loop diuretic for fluid overload instead.
Key facts
Severity
Major — avoid combination
Mechanism
Spironolactone has partial androgen receptor agonist activity that may stimulate prostate cancer cell proliferation, ant...
Action
Avoid spironolactone in patients on abiraterone for prostate cancer; use eplerenone or a loop diuretic for fluid overloa...
Frequently asked questions
Can I take Abiraterone and Spironolactone together?
No — this combination should generally be avoided. Avoid spironolactone in patients on abiraterone for prostate cancer; use eplerenone or a loop diuretic for fluid overload instead.
What is the severity of this interaction?
The interaction between Abiraterone and Spironolactone is classified as Major — avoid combination. Spironolactone has partial androgen receptor agonist activity that may stimulate prostate cancer cell proliferation, antagonising abiraterone's androgen-deprivation effect.
What should I do if I'm prescribed both?
Avoid spironolactone in patients on abiraterone for prostate cancer; use eplerenone or a loop diuretic for fluid overload instead. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.