Ace Inhibitor and Allopurinol: Drug Interaction Guide

Quick answer: This combination requires caution. Ace Inhibitor and Allopurinol can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ace Inhibitor interacts with Allopurinol

Combined use of ACE inhibitors and allopurinol increases the risk of hypersensitivity reactions including Stevens-Johnson syndrome, particularly in renal impairment.

What you should do

Use cautiously, especially in patients with reduced renal function; counsel on rash and hypersensitivity symptoms and reassess if reactions develop.

Key facts

Severity

Moderate — caution required

Mechanism

Combined use of ACE inhibitors and allopurinol increases the risk of hypersensitivity reactions including Stevens-Johnso...

Action

Use cautiously, especially in patients with reduced renal function; counsel on rash and hypersensitivity symptoms and re...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ace Inhibitor and Allopurinol together?

With caution. Use cautiously, especially in patients with reduced renal function; counsel on rash and hypersensitivity symptoms and reassess if reactions develop.

What is the severity of this interaction?

The interaction between Ace Inhibitor and Allopurinol is classified as Moderate — caution required. Combined use of ACE inhibitors and allopurinol increases the risk of hypersensitivity reactions including Stevens-Johnson syndrome, particularly in renal impairment.

What should I do if I'm prescribed both?

Use cautiously, especially in patients with reduced renal function; counsel on rash and hypersensitivity symptoms and reassess if reactions develop. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.