Acetylsalicylic Acid and Lisinopril: Drug Interaction Guide
Quick answer: Acetylsalicylic Acid and Lisinopril have a minor interaction — typically manageable with awareness.
How Acetylsalicylic Acid interacts with Lisinopril
Cyclooxygenase inhibition can reduce renal prostaglandin synthesis and mildly attenuate the antihypertensive effect of lisinopril, particularly at higher acetylsalicylic acid doses.
What you should do
Low antiplatelet doses are generally acceptable. Monitor blood pressure, renal function, and potassium in patients with renal impairment, heart failure, or volume depletion.
Key facts
Severity
Minor — typically manageable
Mechanism
Cyclooxygenase inhibition can reduce renal prostaglandin synthesis and mildly attenuate the antihypertensive effect of l...
Action
Low antiplatelet doses are generally acceptable. Monitor blood pressure, renal function, and potassium in patients with ...
Frequently asked questions
Can I take Acetylsalicylic Acid and Lisinopril together?
Usually yes, with awareness. Low antiplatelet doses are generally acceptable. Monitor blood pressure, renal function, and potassium in patients with renal impairment, heart failure, or volume depletion.
What is the severity of this interaction?
The interaction between Acetylsalicylic Acid and Lisinopril is classified as Minor — typically manageable. Cyclooxygenase inhibition can reduce renal prostaglandin synthesis and mildly attenuate the antihypertensive effect of lisinopril, particularly at higher acetylsalicylic acid doses.
What should I do if I'm prescribed both?
Low antiplatelet doses are generally acceptable. Monitor blood pressure, renal function, and potassium in patients with renal impairment, heart failure, or volume depletion. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.