Acyclovir and Probenecid: Drug Interaction Guide
Quick answer: Acyclovir and Probenecid have a minor interaction — typically manageable with awareness.
How Acyclovir interacts with Probenecid
Probenecid inhibits renal tubular secretion of acyclovir through organic anion transporters, increasing acyclovir exposure and prolonging its half-life.
What you should do
No routine adjustment is needed in patients with normal renal function. Monitor renal function and neurological adverse effects in susceptible patients.
Key facts
Severity
Minor — typically manageable
Mechanism
Probenecid inhibits renal tubular secretion of acyclovir through organic anion transporters, increasing acyclovir exposu...
Action
No routine adjustment is needed in patients with normal renal function. Monitor renal function and neurological adverse ...
Frequently asked questions
Can I take Acyclovir and Probenecid together?
Usually yes, with awareness. No routine adjustment is needed in patients with normal renal function. Monitor renal function and neurological adverse effects in susceptible patients.
What is the severity of this interaction?
The interaction between Acyclovir and Probenecid is classified as Minor — typically manageable. Probenecid inhibits renal tubular secretion of acyclovir through organic anion transporters, increasing acyclovir exposure and prolonging its half-life.
What should I do if I'm prescribed both?
No routine adjustment is needed in patients with normal renal function. Monitor renal function and neurological adverse effects in susceptible patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.