Adenosine and Dipyridamole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Adenosine and Dipyridamole unless specifically directed by your doctor.
How Adenosine interacts with Dipyridamole
Dipyridamole inhibits cellular uptake and metabolism of adenosine, markedly potentiating its negative chronotropic and dromotropic effects.
What you should do
Discontinue dipyridamole at least 24 hours before adenosine administration, or reduce the adenosine dose substantially with continuous cardiac monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Dipyridamole inhibits cellular uptake and metabolism of adenosine, markedly potentiating its negative chronotropic and d...
Action
Discontinue dipyridamole at least 24 hours before adenosine administration, or reduce the adenosine dose substantially w...
Frequently asked questions
Can I take Adenosine and Dipyridamole together?
No — this combination should generally be avoided. Discontinue dipyridamole at least 24 hours before adenosine administration, or reduce the adenosine dose substantially with continuous cardiac monitoring.
What is the severity of this interaction?
The interaction between Adenosine and Dipyridamole is classified as Major — avoid combination. Dipyridamole inhibits cellular uptake and metabolism of adenosine, markedly potentiating its negative chronotropic and dromotropic effects.
What should I do if I'm prescribed both?
Discontinue dipyridamole at least 24 hours before adenosine administration, or reduce the adenosine dose substantially with continuous cardiac monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.