Alfuzosin and Ketoconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Alfuzosin and Ketoconazole unless specifically directed by your doctor.
How Alfuzosin interacts with Ketoconazole
Ketoconazole is a potent CYP3A4 inhibitor that dramatically increases plasma concentrations of alfuzosin, potentiating alpha-1 blockade and risk of severe hypotension and syncope.
What you should do
Combination is contraindicated. Choose an alternative alpha-blocker or alternative antifungal; consider tamsulosin with caution or fluconazole at lower doses with BP monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole is a potent CYP3A4 inhibitor that dramatically increases plasma concentrations of alfuzosin, potentiating a...
Action
Combination is contraindicated. Choose an alternative alpha-blocker or alternative antifungal; consider tamsulosin with ...
Frequently asked questions
Can I take Alfuzosin and Ketoconazole together?
No — this combination should generally be avoided. Combination is contraindicated. Choose an alternative alpha-blocker or alternative antifungal; consider tamsulosin with caution or fluconazole at lower doses with BP monitoring.
What is the severity of this interaction?
The interaction between Alfuzosin and Ketoconazole is classified as Major — avoid combination. Ketoconazole is a potent CYP3A4 inhibitor that dramatically increases plasma concentrations of alfuzosin, potentiating alpha-1 blockade and risk of severe hypotension and syncope.
What should I do if I'm prescribed both?
Combination is contraindicated. Choose an alternative alpha-blocker or alternative antifungal; consider tamsulosin with caution or fluconazole at lower doses with BP monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.