Aluminium Hydroxide and Ciprofloxacin: Drug Interaction Guide

Quick answer: This combination requires caution. Aluminium Hydroxide and Ciprofloxacin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Aluminium Hydroxide interacts with Ciprofloxacin

Aluminium and magnesium antacids chelate fluoroquinolones in the gut, substantially reducing ciprofloxacin absorption and antimicrobial efficacy.

What you should do

Administer ciprofloxacin at least 2 hours before or 6 hours after antacid; consider using an H2 antagonist or PPI instead for acid suppression.

Key facts

Severity

Moderate — caution required

Mechanism

Aluminium and magnesium antacids chelate fluoroquinolones in the gut, substantially reducing ciprofloxacin absorption an...

Action

Administer ciprofloxacin at least 2 hours before or 6 hours after antacid; consider using an H2 antagonist or PPI instea...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Aluminium Hydroxide and Ciprofloxacin together?

With caution. Administer ciprofloxacin at least 2 hours before or 6 hours after antacid; consider using an H2 antagonist or PPI instead for acid suppression.

What is the severity of this interaction?

The interaction between Aluminium Hydroxide and Ciprofloxacin is classified as Moderate — caution required. Aluminium and magnesium antacids chelate fluoroquinolones in the gut, substantially reducing ciprofloxacin absorption and antimicrobial efficacy.

What should I do if I'm prescribed both?

Administer ciprofloxacin at least 2 hours before or 6 hours after antacid; consider using an H2 antagonist or PPI instead for acid suppression. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.