Amiodarone and Sofosbuvir: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Amiodarone and Sofosbuvir unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Amiodarone interacts with Sofosbuvir

Co-administration causes symptomatic bradycardia and heart block via uncharacterised additive effects on sinus node and AV conduction, particularly with daclatasvir or ledipasvir.

What you should do

Avoid the combination; if amiodarone cannot be stopped, monitor ECG in hospital for the first 48 hours of antiviral therapy and for 3 months.

Key facts

Severity

Major — avoid combination

Mechanism

Co-administration causes symptomatic bradycardia and heart block via uncharacterised additive effects on sinus node and ...

Action

Avoid the combination; if amiodarone cannot be stopped, monitor ECG in hospital for the first 48 hours of antiviral ther...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amiodarone and Sofosbuvir together?

No — this combination should generally be avoided. Avoid the combination; if amiodarone cannot be stopped, monitor ECG in hospital for the first 48 hours of antiviral therapy and for 3 months.

What is the severity of this interaction?

The interaction between Amiodarone and Sofosbuvir is classified as Major — avoid combination. Co-administration causes symptomatic bradycardia and heart block via uncharacterised additive effects on sinus node and AV conduction, particularly with daclatasvir or ledipasvir.

What should I do if I'm prescribed both?

Avoid the combination; if amiodarone cannot be stopped, monitor ECG in hospital for the first 48 hours of antiviral therapy and for 3 months. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.