Amitriptyline and Terbinafine: Drug Interaction Guide

Quick answer: This combination requires caution. Amitriptyline and Terbinafine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Amitriptyline interacts with Terbinafine

Terbinafine is a potent CYP2D6 inhibitor that increases amitriptyline and nortriptyline plasma concentrations, raising anticholinergic and cardiac toxicity risk.

What you should do

Reduce tricyclic dose, monitor for anticholinergic side effects and ECG changes, and consider topical antifungal therapy where feasible.

Key facts

Severity

Moderate — caution required

Mechanism

Terbinafine is a potent CYP2D6 inhibitor that increases amitriptyline and nortriptyline plasma concentrations, raising a...

Action

Reduce tricyclic dose, monitor for anticholinergic side effects and ECG changes, and consider topical antifungal therapy...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amitriptyline and Terbinafine together?

With caution. Reduce tricyclic dose, monitor for anticholinergic side effects and ECG changes, and consider topical antifungal therapy where feasible.

What is the severity of this interaction?

The interaction between Amitriptyline and Terbinafine is classified as Moderate — caution required. Terbinafine is a potent CYP2D6 inhibitor that increases amitriptyline and nortriptyline plasma concentrations, raising anticholinergic and cardiac toxicity risk.

What should I do if I'm prescribed both?

Reduce tricyclic dose, monitor for anticholinergic side effects and ECG changes, and consider topical antifungal therapy where feasible. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.