Amlodipine and Grapefruit Juice: Drug Interaction Guide
Quick answer: Amlodipine and Grapefruit Juice have a minor interaction — typically manageable with awareness.
How Amlodipine interacts with Grapefruit Juice
Grapefruit juice inhibits intestinal CYP3A4, modestly increasing amlodipine AUC by 15-20%, far less than its effect on felodipine.
What you should do
Clinically insignificant for most patients; routine restriction is not required, but counsel patients with marked hypotension or in older age groups to limit large grapefruit juice intake.
Key facts
Severity
Minor — typically manageable
Mechanism
Grapefruit juice inhibits intestinal CYP3A4, modestly increasing amlodipine AUC by 15-20%, far less than its effect on f...
Action
Clinically insignificant for most patients; routine restriction is not required, but counsel patients with marked hypote...
Frequently asked questions
Can I take Amlodipine and Grapefruit Juice together?
Usually yes, with awareness. Clinically insignificant for most patients; routine restriction is not required, but counsel patients with marked hypotension or in older age groups to limit large grapefruit juice intake.
What is the severity of this interaction?
The interaction between Amlodipine and Grapefruit Juice is classified as Minor — typically manageable. Grapefruit juice inhibits intestinal CYP3A4, modestly increasing amlodipine AUC by 15-20%, far less than its effect on felodipine.
What should I do if I'm prescribed both?
Clinically insignificant for most patients; routine restriction is not required, but counsel patients with marked hypotension or in older age groups to limit large grapefruit juice intake. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.