Amlodipine and Tacrolimus: Drug Interaction Guide

Quick answer: This combination requires caution. Amlodipine and Tacrolimus can be used together with adjustments and monitoring.

How Amlodipine interacts with Tacrolimus

Amlodipine modestly inhibits CYP3A4 and competes for P-glycoprotein, raising tacrolimus trough concentrations and nephrotoxicity risk.

What you should do

Monitor tacrolimus trough levels weekly after initiating or dose-changing amlodipine and adjust tacrolimus dose accordingly.

Key facts

Severity

Moderate — caution required

Mechanism

Amlodipine modestly inhibits CYP3A4 and competes for P-glycoprotein, raising tacrolimus trough concentrations and nephro...

Action

Monitor tacrolimus trough levels weekly after initiating or dose-changing amlodipine and adjust tacrolimus dose accordin...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amlodipine and Tacrolimus together?

With caution. Monitor tacrolimus trough levels weekly after initiating or dose-changing amlodipine and adjust tacrolimus dose accordingly.

What is the severity of this interaction?

The interaction between Amlodipine and Tacrolimus is classified as Moderate — caution required. Amlodipine modestly inhibits CYP3A4 and competes for P-glycoprotein, raising tacrolimus trough concentrations and nephrotoxicity risk.

What should I do if I'm prescribed both?

Monitor tacrolimus trough levels weekly after initiating or dose-changing amlodipine and adjust tacrolimus dose accordingly. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 17, 2026 by iMedic Medical Editorial Team. Our editorial process.