Aspirin and Methotrexate: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Aspirin and Methotrexate unless specifically directed by your doctor.
How Aspirin interacts with Methotrexate
Aspirin and other NSAIDs reduce renal clearance of methotrexate by inhibiting tubular secretion and displace methotrexate from plasma protein binding, increasing systemic exposure and toxicity.
What you should do
Avoid concurrent use, particularly with high-dose methotrexate. With low-dose weekly methotrexate, monitor full blood count, renal function, and liver enzymes closely.
Key facts
Severity
Major — avoid combination
Mechanism
Aspirin and other NSAIDs reduce renal clearance of methotrexate by inhibiting tubular secretion and displace methotrexat...
Action
Avoid concurrent use, particularly with high-dose methotrexate. With low-dose weekly methotrexate, monitor full blood co...
Frequently asked questions
Can I take Aspirin and Methotrexate together?
No — this combination should generally be avoided. Avoid concurrent use, particularly with high-dose methotrexate. With low-dose weekly methotrexate, monitor full blood count, renal function, and liver enzymes closely.
What is the severity of this interaction?
The interaction between Aspirin and Methotrexate is classified as Major — avoid combination. Aspirin and other NSAIDs reduce renal clearance of methotrexate by inhibiting tubular secretion and displace methotrexate from plasma protein binding, increasing systemic exposure and toxicity.
What should I do if I'm prescribed both?
Avoid concurrent use, particularly with high-dose methotrexate. With low-dose weekly methotrexate, monitor full blood count, renal function, and liver enzymes closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.