Aspirin and Ramipril: Drug Interaction Guide
Quick answer: Aspirin and Ramipril have a minor interaction — typically manageable with awareness.
How Aspirin interacts with Ramipril
High-dose aspirin inhibits cyclo-oxygenase-mediated renal prostaglandin synthesis, blunting the vasodilatory and natriuretic effects of ACE inhibitors; low-dose aspirin has minimal clinical impact.
What you should do
Low-dose aspirin (≤100 mg) for cardiovascular prevention can be continued. Avoid analgesic doses of aspirin in heart failure; monitor blood pressure and renal function.
Key facts
Severity
Minor — typically manageable
Mechanism
High-dose aspirin inhibits cyclo-oxygenase-mediated renal prostaglandin synthesis, blunting the vasodilatory and natriur...
Action
Low-dose aspirin (≤100 mg) for cardiovascular prevention can be continued. Avoid analgesic doses of aspirin in heart fai...
Frequently asked questions
Can I take Aspirin and Ramipril together?
Usually yes, with awareness. Low-dose aspirin (≤100 mg) for cardiovascular prevention can be continued. Avoid analgesic doses of aspirin in heart failure; monitor blood pressure and renal function.
What is the severity of this interaction?
The interaction between Aspirin and Ramipril is classified as Minor — typically manageable. High-dose aspirin inhibits cyclo-oxygenase-mediated renal prostaglandin synthesis, blunting the vasodilatory and natriuretic effects of ACE inhibitors; low-dose aspirin has minimal clinical impact.
What should I do if I'm prescribed both?
Low-dose aspirin (≤100 mg) for cardiovascular prevention can be continued. Avoid analgesic doses of aspirin in heart failure; monitor blood pressure and renal function. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.