Atazanavir and Pantoprazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Atazanavir and Pantoprazole unless specifically directed by your doctor.
How Atazanavir interacts with Pantoprazole
Proton-pump inhibitors raise gastric pH and reduce dissolution of atazanavir, decreasing its AUC by up to 76% and risking virologic failure.
What you should do
Avoid PPIs with unboosted atazanavir; in treatment-naïve patients on ritonavir-boosted atazanavir, limit PPI to omeprazole 20 mg equivalent and give 12 hours before atazanavir.
Key facts
Severity
Major — avoid combination
Mechanism
Proton-pump inhibitors raise gastric pH and reduce dissolution of atazanavir, decreasing its AUC by up to 76% and riskin...
Action
Avoid PPIs with unboosted atazanavir; in treatment-naïve patients on ritonavir-boosted atazanavir, limit PPI to omeprazo...
Frequently asked questions
Can I take Atazanavir and Pantoprazole together?
No — this combination should generally be avoided. Avoid PPIs with unboosted atazanavir; in treatment-naïve patients on ritonavir-boosted atazanavir, limit PPI to omeprazole 20 mg equivalent and give 12 hours before atazanavir.
What is the severity of this interaction?
The interaction between Atazanavir and Pantoprazole is classified as Major — avoid combination. Proton-pump inhibitors raise gastric pH and reduce dissolution of atazanavir, decreasing its AUC by up to 76% and risking virologic failure.
What should I do if I'm prescribed both?
Avoid PPIs with unboosted atazanavir; in treatment-naïve patients on ritonavir-boosted atazanavir, limit PPI to omeprazole 20 mg equivalent and give 12 hours before atazanavir. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.