Azathioprine and Febuxostat: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Azathioprine and Febuxostat unless specifically directed by your doctor.
How Azathioprine interacts with Febuxostat
Febuxostat inhibits xanthine oxidase, the enzyme that inactivates azathioprine's metabolite 6-mercaptopurine, leading to accumulation and severe myelosuppression.
What you should do
The combination is contraindicated; manage hyperuricaemia with alternative agents such as low-dose probenecid, or substitute mycophenolate for azathioprine.
Key facts
Severity
Major — avoid combination
Mechanism
Febuxostat inhibits xanthine oxidase, the enzyme that inactivates azathioprine's metabolite 6-mercaptopurine, leading to...
Action
The combination is contraindicated; manage hyperuricaemia with alternative agents such as low-dose probenecid, or substi...
Frequently asked questions
Can I take Azathioprine and Febuxostat together?
No — this combination should generally be avoided. The combination is contraindicated; manage hyperuricaemia with alternative agents such as low-dose probenecid, or substitute mycophenolate for azathioprine.
What is the severity of this interaction?
The interaction between Azathioprine and Febuxostat is classified as Major — avoid combination. Febuxostat inhibits xanthine oxidase, the enzyme that inactivates azathioprine's metabolite 6-mercaptopurine, leading to accumulation and severe myelosuppression.
What should I do if I'm prescribed both?
The combination is contraindicated; manage hyperuricaemia with alternative agents such as low-dose probenecid, or substitute mycophenolate for azathioprine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.