Bupropion and Tamoxifen: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Bupropion and Tamoxifen unless specifically directed by your doctor.
How Bupropion interacts with Tamoxifen
Bupropion is a strong CYP2D6 inhibitor that blocks conversion of tamoxifen to its active metabolite endoxifen, reducing breast cancer recurrence protection.
What you should do
Avoid bupropion in women on adjuvant tamoxifen; choose a non-CYP2D6 inhibiting antidepressant such as venlafaxine or escitalopram if pharmacotherapy is required.
Key facts
Severity
Major — avoid combination
Mechanism
Bupropion is a strong CYP2D6 inhibitor that blocks conversion of tamoxifen to its active metabolite endoxifen, reducing ...
Action
Avoid bupropion in women on adjuvant tamoxifen; choose a non-CYP2D6 inhibiting antidepressant such as venlafaxine or esc...
Frequently asked questions
Can I take Bupropion and Tamoxifen together?
No — this combination should generally be avoided. Avoid bupropion in women on adjuvant tamoxifen; choose a non-CYP2D6 inhibiting antidepressant such as venlafaxine or escitalopram if pharmacotherapy is required.
What is the severity of this interaction?
The interaction between Bupropion and Tamoxifen is classified as Major — avoid combination. Bupropion is a strong CYP2D6 inhibitor that blocks conversion of tamoxifen to its active metabolite endoxifen, reducing breast cancer recurrence protection.
What should I do if I'm prescribed both?
Avoid bupropion in women on adjuvant tamoxifen; choose a non-CYP2D6 inhibiting antidepressant such as venlafaxine or escitalopram if pharmacotherapy is required. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.