Captopril and Lithium: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Captopril and Lithium unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Captopril interacts with Lithium

ACE inhibitors reduce renal sodium availability and glomerular filtration, decreasing renal lithium clearance and raising serum lithium up to 4-fold.

What you should do

Avoid if possible; if combined, check lithium level within 5-7 days of starting and after any dose change, and reduce lithium dose proactively.

Key facts

Severity

Major — avoid combination

Mechanism

ACE inhibitors reduce renal sodium availability and glomerular filtration, decreasing renal lithium clearance and raisin...

Action

Avoid if possible; if combined, check lithium level within 5-7 days of starting and after any dose change, and reduce li...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Captopril and Lithium together?

No — this combination should generally be avoided. Avoid if possible; if combined, check lithium level within 5-7 days of starting and after any dose change, and reduce lithium dose proactively.

What is the severity of this interaction?

The interaction between Captopril and Lithium is classified as Major — avoid combination. ACE inhibitors reduce renal sodium availability and glomerular filtration, decreasing renal lithium clearance and raising serum lithium up to 4-fold.

What should I do if I'm prescribed both?

Avoid if possible; if combined, check lithium level within 5-7 days of starting and after any dose change, and reduce lithium dose proactively. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.