Ciclosporin and Tacrolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciclosporin and Tacrolimus unless specifically directed by your doctor.
How Ciclosporin interacts with Tacrolimus
Both drugs inhibit calcineurin and have overlapping nephrotoxic, neurotoxic, and immunosuppressive effects; shared CYP3A and P-glycoprotein disposition may further increase exposure.
What you should do
Avoid concomitant administration. Allow an appropriate washout when switching and monitor renal function and drug concentrations.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs inhibit calcineurin and have overlapping nephrotoxic, neurotoxic, and immunosuppressive effects; shared CYP3A...
Action
Avoid concomitant administration. Allow an appropriate washout when switching and monitor renal function and drug concen...
Frequently asked questions
Can I take Ciclosporin and Tacrolimus together?
No — this combination should generally be avoided. Avoid concomitant administration. Allow an appropriate washout when switching and monitor renal function and drug concentrations.
What is the severity of this interaction?
The interaction between Ciclosporin and Tacrolimus is classified as Major — avoid combination. Both drugs inhibit calcineurin and have overlapping nephrotoxic, neurotoxic, and immunosuppressive effects; shared CYP3A and P-glycoprotein disposition may further increase exposure.
What should I do if I'm prescribed both?
Avoid concomitant administration. Allow an appropriate washout when switching and monitor renal function and drug concentrations. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.