Cisplatin and Furosemide: Drug Interaction Guide

Quick answer: This combination requires caution. Cisplatin and Furosemide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Cisplatin interacts with Furosemide

Cisplatin and furosemide both cause direct cochlear hair cell damage, producing additive irreversible ototoxicity, particularly at high cisplatin doses.

What you should do

Use mannitol rather than loop diuretics for cisplatin-induced fluid overload when feasible; baseline and follow-up audiometry in prolonged therapy.

Key facts

Severity

Moderate — caution required

Mechanism

Cisplatin and furosemide both cause direct cochlear hair cell damage, producing additive irreversible ototoxicity, parti...

Action

Use mannitol rather than loop diuretics for cisplatin-induced fluid overload when feasible; baseline and follow-up audio...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cisplatin and Furosemide together?

With caution. Use mannitol rather than loop diuretics for cisplatin-induced fluid overload when feasible; baseline and follow-up audiometry in prolonged therapy.

What is the severity of this interaction?

The interaction between Cisplatin and Furosemide is classified as Moderate — caution required. Cisplatin and furosemide both cause direct cochlear hair cell damage, producing additive irreversible ototoxicity, particularly at high cisplatin doses.

What should I do if I'm prescribed both?

Use mannitol rather than loop diuretics for cisplatin-induced fluid overload when feasible; baseline and follow-up audiometry in prolonged therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.