Dabigatran and Ketoconazole: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Dabigatran and Ketoconazole unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Dabigatran interacts with Ketoconazole

Ketoconazole is a strong P-glycoprotein inhibitor that significantly increases dabigatran plasma concentrations, raising bleeding risk.

What you should do

Avoid combination. If necessary, contraindicated per label in patients with CrCl <50 mL/min.

Key facts

Severity

Major — avoid combination

Mechanism

Ketoconazole is a strong P-glycoprotein inhibitor that significantly increases dabigatran plasma concentrations, raising...

Action

Avoid combination. If necessary, contraindicated per label in patients with CrCl <50 mL/min.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Dabigatran and Ketoconazole together?

No — this combination should generally be avoided. Avoid combination. If necessary, contraindicated per label in patients with CrCl <50 mL/min.

What is the severity of this interaction?

The interaction between Dabigatran and Ketoconazole is classified as Major — avoid combination. Ketoconazole is a strong P-glycoprotein inhibitor that significantly increases dabigatran plasma concentrations, raising bleeding risk.

What should I do if I'm prescribed both?

Avoid combination. If necessary, contraindicated per label in patients with CrCl <50 mL/min. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.