Diclofenac and Lithium: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Diclofenac and Lithium unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Diclofenac interacts with Lithium

NSAIDs reduce renal prostaglandin synthesis, decreasing glomerular filtration and tubular lithium clearance, elevating serum lithium by 25-60%.

What you should do

Avoid combination where possible. If required, monitor lithium levels within 5-7 days of starting/stopping NSAID and adjust dose accordingly.

Key facts

Severity

Major — avoid combination

Mechanism

NSAIDs reduce renal prostaglandin synthesis, decreasing glomerular filtration and tubular lithium clearance, elevating s...

Action

Avoid combination where possible. If required, monitor lithium levels within 5-7 days of starting/stopping NSAID and adj...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diclofenac and Lithium together?

No — this combination should generally be avoided. Avoid combination where possible. If required, monitor lithium levels within 5-7 days of starting/stopping NSAID and adjust dose accordingly.

What is the severity of this interaction?

The interaction between Diclofenac and Lithium is classified as Major — avoid combination. NSAIDs reduce renal prostaglandin synthesis, decreasing glomerular filtration and tubular lithium clearance, elevating serum lithium by 25-60%.

What should I do if I'm prescribed both?

Avoid combination where possible. If required, monitor lithium levels within 5-7 days of starting/stopping NSAID and adjust dose accordingly. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.