Diclofenac and Methotrexate: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Diclofenac and Methotrexate unless specifically directed by your doctor.
How Diclofenac interacts with Methotrexate
NSAIDs reduce renal perfusion and compete for tubular secretion, decreasing methotrexate clearance and raising plasma levels with risk of bone marrow suppression and mucositis.
What you should do
Avoid NSAIDs during high-dose methotrexate; with low-dose weekly methotrexate, use cautiously and monitor full blood count and renal function.
Key facts
Severity
Major — avoid combination
Mechanism
NSAIDs reduce renal perfusion and compete for tubular secretion, decreasing methotrexate clearance and raising plasma le...
Action
Avoid NSAIDs during high-dose methotrexate; with low-dose weekly methotrexate, use cautiously and monitor full blood cou...
Frequently asked questions
Can I take Diclofenac and Methotrexate together?
No — this combination should generally be avoided. Avoid NSAIDs during high-dose methotrexate; with low-dose weekly methotrexate, use cautiously and monitor full blood count and renal function.
What is the severity of this interaction?
The interaction between Diclofenac and Methotrexate is classified as Major — avoid combination. NSAIDs reduce renal perfusion and compete for tubular secretion, decreasing methotrexate clearance and raising plasma levels with risk of bone marrow suppression and mucositis.
What should I do if I'm prescribed both?
Avoid NSAIDs during high-dose methotrexate; with low-dose weekly methotrexate, use cautiously and monitor full blood count and renal function. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.