Diclofenac and Ramipril: Drug Interaction Guide

Quick answer: This combination requires caution. Diclofenac and Ramipril can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diclofenac interacts with Ramipril

NSAIDs inhibit renal prostaglandin synthesis, blunting the antihypertensive effect of ramipril and increasing risk of acute kidney injury, especially with diuretics.

What you should do

Use paracetamol for analgesia where possible; if NSAID required, limit duration, monitor blood pressure and renal function within 1-2 weeks.

Key facts

Severity

Moderate — caution required

Mechanism

NSAIDs inhibit renal prostaglandin synthesis, blunting the antihypertensive effect of ramipril and increasing risk of ac...

Action

Use paracetamol for analgesia where possible; if NSAID required, limit duration, monitor blood pressure and renal functi...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diclofenac and Ramipril together?

With caution. Use paracetamol for analgesia where possible; if NSAID required, limit duration, monitor blood pressure and renal function within 1-2 weeks.

What is the severity of this interaction?

The interaction between Diclofenac and Ramipril is classified as Moderate — caution required. NSAIDs inhibit renal prostaglandin synthesis, blunting the antihypertensive effect of ramipril and increasing risk of acute kidney injury, especially with diuretics.

What should I do if I'm prescribed both?

Use paracetamol for analgesia where possible; if NSAID required, limit duration, monitor blood pressure and renal function within 1-2 weeks. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.