Digoxin and Spironolactone: Drug Interaction Guide

Quick answer: This combination requires caution. Digoxin and Spironolactone can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Digoxin interacts with Spironolactone

Spironolactone inhibits P-glycoprotein-mediated tubular secretion of digoxin and can interfere with some digoxin immunoassays, raising serum digoxin levels.

What you should do

Monitor serum digoxin levels and signs of toxicity (nausea, visual changes, arrhythmias); consider digoxin dose reduction of 25%.

Key facts

Severity

Moderate — caution required

Mechanism

Spironolactone inhibits P-glycoprotein-mediated tubular secretion of digoxin and can interfere with some digoxin immunoa...

Action

Monitor serum digoxin levels and signs of toxicity (nausea, visual changes, arrhythmias); consider digoxin dose reductio...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Digoxin and Spironolactone together?

With caution. Monitor serum digoxin levels and signs of toxicity (nausea, visual changes, arrhythmias); consider digoxin dose reduction of 25%.

What is the severity of this interaction?

The interaction between Digoxin and Spironolactone is classified as Moderate — caution required. Spironolactone inhibits P-glycoprotein-mediated tubular secretion of digoxin and can interfere with some digoxin immunoassays, raising serum digoxin levels.

What should I do if I'm prescribed both?

Monitor serum digoxin levels and signs of toxicity (nausea, visual changes, arrhythmias); consider digoxin dose reduction of 25%. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.