Dolutegravir and Ferrous Sulfate: Drug Interaction Guide

Quick answer: This combination requires caution. Dolutegravir and Ferrous Sulfate can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Dolutegravir interacts with Ferrous Sulfate

Dolutegravir chelates polyvalent iron cations in the gastrointestinal tract, forming poorly absorbed complexes and reducing dolutegravir exposure.

What you should do

Administer dolutegravir at least two hours before or six hours after iron. They may be taken together with food if permitted by the applicable treatment guidance.

Key facts

Severity

Moderate — caution required

Mechanism

Dolutegravir chelates polyvalent iron cations in the gastrointestinal tract, forming poorly absorbed complexes and reduc...

Action

Administer dolutegravir at least two hours before or six hours after iron. They may be taken together with food if permi...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Dolutegravir and Ferrous Sulfate together?

With caution. Administer dolutegravir at least two hours before or six hours after iron. They may be taken together with food if permitted by the applicable treatment guidance.

What is the severity of this interaction?

The interaction between Dolutegravir and Ferrous Sulfate is classified as Moderate — caution required. Dolutegravir chelates polyvalent iron cations in the gastrointestinal tract, forming poorly absorbed complexes and reducing dolutegravir exposure.

What should I do if I'm prescribed both?

Administer dolutegravir at least two hours before or six hours after iron. They may be taken together with food if permitted by the applicable treatment guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.