Dolutegravir and Metformin: Drug Interaction Guide
Quick answer: This combination requires caution. Dolutegravir and Metformin can be used together with adjustments and monitoring.
How Dolutegravir interacts with Metformin
Dolutegravir inhibits OCT2 and MATE1 transporters responsible for renal metformin excretion, increasing metformin plasma concentrations.
What you should do
Limit metformin to 1000 mg daily when coadministered with dolutegravir; monitor for lactic acidosis and gastrointestinal effects.
Key facts
Severity
Moderate — caution required
Mechanism
Dolutegravir inhibits OCT2 and MATE1 transporters responsible for renal metformin excretion, increasing metformin plasma...
Action
Limit metformin to 1000 mg daily when coadministered with dolutegravir; monitor for lactic acidosis and gastrointestinal...
Frequently asked questions
Can I take Dolutegravir and Metformin together?
With caution. Limit metformin to 1000 mg daily when coadministered with dolutegravir; monitor for lactic acidosis and gastrointestinal effects.
What is the severity of this interaction?
The interaction between Dolutegravir and Metformin is classified as Moderate — caution required. Dolutegravir inhibits OCT2 and MATE1 transporters responsible for renal metformin excretion, increasing metformin plasma concentrations.
What should I do if I'm prescribed both?
Limit metformin to 1000 mg daily when coadministered with dolutegravir; monitor for lactic acidosis and gastrointestinal effects. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.