Domperidone and Ketoconazole: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Domperidone and Ketoconazole unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Domperidone interacts with Ketoconazole

Ketoconazole inhibits CYP3A4 metabolism of domperidone, increasing plasma levels and the risk of dose-dependent QT prolongation and torsades de pointes.

What you should do

Contraindicated combination. Use alternative antifungal or antiemetic, and review concurrent QT-prolonging drugs and electrolytes.

Key facts

Severity

Major — avoid combination

Mechanism

Ketoconazole inhibits CYP3A4 metabolism of domperidone, increasing plasma levels and the risk of dose-dependent QT prolo...

Action

Contraindicated combination. Use alternative antifungal or antiemetic, and review concurrent QT-prolonging drugs and ele...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Domperidone and Ketoconazole together?

No — this combination should generally be avoided. Contraindicated combination. Use alternative antifungal or antiemetic, and review concurrent QT-prolonging drugs and electrolytes.

What is the severity of this interaction?

The interaction between Domperidone and Ketoconazole is classified as Major — avoid combination. Ketoconazole inhibits CYP3A4 metabolism of domperidone, increasing plasma levels and the risk of dose-dependent QT prolongation and torsades de pointes.

What should I do if I'm prescribed both?

Contraindicated combination. Use alternative antifungal or antiemetic, and review concurrent QT-prolonging drugs and electrolytes. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.