Edoxaban and Ketoconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Edoxaban and Ketoconazole unless specifically directed by your doctor.
How Edoxaban interacts with Ketoconazole
Ketoconazole strongly inhibits intestinal P-glycoprotein, increasing edoxaban absorption and systemic exposure by approximately 90%, raising the risk of major bleeding.
What you should do
Reduce edoxaban dose to 30 mg once daily during concomitant ketoconazole therapy, or select a non-P-gp-dependent antifungal where appropriate.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole strongly inhibits intestinal P-glycoprotein, increasing edoxaban absorption and systemic exposure by approx...
Action
Reduce edoxaban dose to 30 mg once daily during concomitant ketoconazole therapy, or select a non-P-gp-dependent antifun...
Frequently asked questions
Can I take Edoxaban and Ketoconazole together?
No — this combination should generally be avoided. Reduce edoxaban dose to 30 mg once daily during concomitant ketoconazole therapy, or select a non-P-gp-dependent antifungal where appropriate.
What is the severity of this interaction?
The interaction between Edoxaban and Ketoconazole is classified as Major — avoid combination. Ketoconazole strongly inhibits intestinal P-glycoprotein, increasing edoxaban absorption and systemic exposure by approximately 90%, raising the risk of major bleeding.
What should I do if I'm prescribed both?
Reduce edoxaban dose to 30 mg once daily during concomitant ketoconazole therapy, or select a non-P-gp-dependent antifungal where appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.