Enalapril and Ibuprofen: Drug Interaction Guide

Quick answer: This combination requires caution. Enalapril and Ibuprofen can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Enalapril interacts with Ibuprofen

NSAIDs inhibit renal prostaglandin synthesis, reducing the vasodilatory effect on afferent arterioles and antagonizing the antihypertensive and renoprotective effects of ACE inhibitors. The combination also increases risk of acute kidney injury.

What you should do

Avoid chronic NSAID use with ACE inhibitors when possible, particularly in elderly or volume-depleted patients. If unavoidable, monitor renal function, potassium, and blood pressure.

Key facts

Severity

Moderate — caution required

Mechanism

NSAIDs inhibit renal prostaglandin synthesis, reducing the vasodilatory effect on afferent arterioles and antagonizing t...

Action

Avoid chronic NSAID use with ACE inhibitors when possible, particularly in elderly or volume-depleted patients. If unavo...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Enalapril and Ibuprofen together?

With caution. Avoid chronic NSAID use with ACE inhibitors when possible, particularly in elderly or volume-depleted patients. If unavoidable, monitor renal function, potassium, and blood pressure.

What is the severity of this interaction?

The interaction between Enalapril and Ibuprofen is classified as Moderate — caution required. NSAIDs inhibit renal prostaglandin synthesis, reducing the vasodilatory effect on afferent arterioles and antagonizing the antihypertensive and renoprotective effects of ACE inhibitors. The combination also increases risk of acute kidney injury.

What should I do if I'm prescribed both?

Avoid chronic NSAID use with ACE inhibitors when possible, particularly in elderly or volume-depleted patients. If unavoidable, monitor renal function, potassium, and blood pressure. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.