Eplerenone and Ketoconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Eplerenone and Ketoconazole unless specifically directed by your doctor.
How Eplerenone interacts with Ketoconazole
Ketoconazole strongly inhibits CYP3A4, markedly increasing eplerenone exposure and hyperkalemia risk.
What you should do
Do not co-prescribe. Choose an alternative antifungal or an alternative mineralocorticoid receptor antagonist strategy with potassium monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole strongly inhibits CYP3A4, markedly increasing eplerenone exposure and hyperkalemia risk.
Action
Do not co-prescribe. Choose an alternative antifungal or an alternative mineralocorticoid receptor antagonist strategy w...
Frequently asked questions
Can I take Eplerenone and Ketoconazole together?
No — this combination should generally be avoided. Do not co-prescribe. Choose an alternative antifungal or an alternative mineralocorticoid receptor antagonist strategy with potassium monitoring.
What is the severity of this interaction?
The interaction between Eplerenone and Ketoconazole is classified as Major — avoid combination. Ketoconazole strongly inhibits CYP3A4, markedly increasing eplerenone exposure and hyperkalemia risk.
What should I do if I'm prescribed both?
Do not co-prescribe. Choose an alternative antifungal or an alternative mineralocorticoid receptor antagonist strategy with potassium monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.