Ethanol and Metronidazole: Drug Interaction Guide

Quick answer: This combination requires caution. Ethanol and Metronidazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ethanol interacts with Metronidazole

Metronidazole inhibits acetaldehyde dehydrogenase, leading to acetaldehyde accumulation and a disulfiram-like reaction (flushing, nausea, palpitations, hypotension).

What you should do

Avoid alcohol during and for 48 hours after metronidazole therapy; counsel patients explicitly including alcohol in oral medications and mouthwashes.

Key facts

Severity

Moderate — caution required

Mechanism

Metronidazole inhibits acetaldehyde dehydrogenase, leading to acetaldehyde accumulation and a disulfiram-like reaction (...

Action

Avoid alcohol during and for 48 hours after metronidazole therapy; counsel patients explicitly including alcohol in oral...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ethanol and Metronidazole together?

With caution. Avoid alcohol during and for 48 hours after metronidazole therapy; counsel patients explicitly including alcohol in oral medications and mouthwashes.

What is the severity of this interaction?

The interaction between Ethanol and Metronidazole is classified as Moderate — caution required. Metronidazole inhibits acetaldehyde dehydrogenase, leading to acetaldehyde accumulation and a disulfiram-like reaction (flushing, nausea, palpitations, hypotension).

What should I do if I'm prescribed both?

Avoid alcohol during and for 48 hours after metronidazole therapy; counsel patients explicitly including alcohol in oral medications and mouthwashes. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.