Ezetimibe and Gemfibrozil: Drug Interaction Guide

Quick answer: This combination requires caution. Ezetimibe and Gemfibrozil can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ezetimibe interacts with Gemfibrozil

Gemfibrozil inhibits OATP1B1 and glucuronidation of ezetimibe, increasing its plasma concentration and risk of gallbladder disease and myopathy.

What you should do

Avoid combination if possible; if needed, prefer fenofibrate which has less impact on ezetimibe pharmacokinetics.

Key facts

Severity

Moderate — caution required

Mechanism

Gemfibrozil inhibits OATP1B1 and glucuronidation of ezetimibe, increasing its plasma concentration and risk of gallbladd...

Action

Avoid combination if possible; if needed, prefer fenofibrate which has less impact on ezetimibe pharmacokinetics.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ezetimibe and Gemfibrozil together?

With caution. Avoid combination if possible; if needed, prefer fenofibrate which has less impact on ezetimibe pharmacokinetics.

What is the severity of this interaction?

The interaction between Ezetimibe and Gemfibrozil is classified as Moderate — caution required. Gemfibrozil inhibits OATP1B1 and glucuronidation of ezetimibe, increasing its plasma concentration and risk of gallbladder disease and myopathy.

What should I do if I'm prescribed both?

Avoid combination if possible; if needed, prefer fenofibrate which has less impact on ezetimibe pharmacokinetics. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.