Famotidine and Itraconazole: Drug Interaction Guide
Quick answer: This combination requires caution. Famotidine and Itraconazole can be used together with adjustments and monitoring.
How Famotidine interacts with Itraconazole
Famotidine raises gastric pH and can reduce dissolution and absorption of itraconazole capsules, lowering systemic antifungal exposure.
What you should do
Avoid the capsule formulation with acid suppression when possible, separate administration, or use an itraconazole formulation less dependent on gastric acidity and monitor clinical response.
Key facts
Severity
Moderate — caution required
Mechanism
Famotidine raises gastric pH and can reduce dissolution and absorption of itraconazole capsules, lowering systemic antif...
Action
Avoid the capsule formulation with acid suppression when possible, separate administration, or use an itraconazole formu...
Frequently asked questions
Can I take Famotidine and Itraconazole together?
With caution. Avoid the capsule formulation with acid suppression when possible, separate administration, or use an itraconazole formulation less dependent on gastric acidity and monitor clinical response.
What is the severity of this interaction?
The interaction between Famotidine and Itraconazole is classified as Moderate — caution required. Famotidine raises gastric pH and can reduce dissolution and absorption of itraconazole capsules, lowering systemic antifungal exposure.
What should I do if I'm prescribed both?
Avoid the capsule formulation with acid suppression when possible, separate administration, or use an itraconazole formulation less dependent on gastric acidity and monitor clinical response. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.