Fluconazole and Glipizide: Drug Interaction Guide

Quick answer: This combination requires caution. Fluconazole and Glipizide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Fluconazole interacts with Glipizide

Fluconazole inhibits CYP2C9, reducing metabolism of the sulfonylurea glipizide and prolonging its hypoglycaemic effect.

What you should do

Warn patients of hypoglycaemia risk, monitor capillary glucose closely and consider reducing the sulfonylurea dose during antifungal therapy.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C9, reducing metabolism of the sulfonylurea glipizide and prolonging its hypoglycaemic effect.

Action

Warn patients of hypoglycaemia risk, monitor capillary glucose closely and consider reducing the sulfonylurea dose durin...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluconazole and Glipizide together?

With caution. Warn patients of hypoglycaemia risk, monitor capillary glucose closely and consider reducing the sulfonylurea dose during antifungal therapy.

What is the severity of this interaction?

The interaction between Fluconazole and Glipizide is classified as Moderate — caution required. Fluconazole inhibits CYP2C9, reducing metabolism of the sulfonylurea glipizide and prolonging its hypoglycaemic effect.

What should I do if I'm prescribed both?

Warn patients of hypoglycaemia risk, monitor capillary glucose closely and consider reducing the sulfonylurea dose during antifungal therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.