Fluconazole and Losartan: Drug Interaction Guide

Quick answer: This combination requires caution. Fluconazole and Losartan can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Fluconazole interacts with Losartan

Fluconazole inhibits CYP2C9, reducing conversion of losartan to its more active metabolite. This may reduce antihypertensive effect.

What you should do

Monitor blood pressure and clinical response during coadministration. Consider an antihypertensive not dependent on CYP2C9 activation if control worsens.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C9, reducing conversion of losartan to its more active metabolite. This may reduce antihyperten...

Action

Monitor blood pressure and clinical response during coadministration. Consider an antihypertensive not dependent on CYP2...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluconazole and Losartan together?

With caution. Monitor blood pressure and clinical response during coadministration. Consider an antihypertensive not dependent on CYP2C9 activation if control worsens.

What is the severity of this interaction?

The interaction between Fluconazole and Losartan is classified as Moderate — caution required. Fluconazole inhibits CYP2C9, reducing conversion of losartan to its more active metabolite. This may reduce antihypertensive effect.

What should I do if I'm prescribed both?

Monitor blood pressure and clinical response during coadministration. Consider an antihypertensive not dependent on CYP2C9 activation if control worsens. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.