Fluvoxamine and Olanzapine: Drug Interaction Guide
Quick answer: This combination requires caution. Fluvoxamine and Olanzapine can be used together with adjustments and monitoring.
How Fluvoxamine interacts with Olanzapine
Fluvoxamine is a potent CYP1A2 inhibitor that decreases olanzapine clearance, increasing plasma levels 2-3 fold and risk of sedation, weight gain and metabolic adverse effects.
What you should do
Reduce olanzapine dose by approximately 50% when adding fluvoxamine and monitor for sedation, orthostasis and metabolic parameters.
Key facts
Severity
Moderate — caution required
Mechanism
Fluvoxamine is a potent CYP1A2 inhibitor that decreases olanzapine clearance, increasing plasma levels 2-3 fold and risk...
Action
Reduce olanzapine dose by approximately 50% when adding fluvoxamine and monitor for sedation, orthostasis and metabolic ...
Frequently asked questions
Can I take Fluvoxamine and Olanzapine together?
With caution. Reduce olanzapine dose by approximately 50% when adding fluvoxamine and monitor for sedation, orthostasis and metabolic parameters.
What is the severity of this interaction?
The interaction between Fluvoxamine and Olanzapine is classified as Moderate — caution required. Fluvoxamine is a potent CYP1A2 inhibitor that decreases olanzapine clearance, increasing plasma levels 2-3 fold and risk of sedation, weight gain and metabolic adverse effects.
What should I do if I'm prescribed both?
Reduce olanzapine dose by approximately 50% when adding fluvoxamine and monitor for sedation, orthostasis and metabolic parameters. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.