Glibenclamide and Trimethoprim: Drug Interaction Guide

Quick answer: This combination requires caution. Glibenclamide and Trimethoprim can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Glibenclamide interacts with Trimethoprim

Trimethoprim inhibits CYP2C9-mediated metabolism of glibenclamide, increasing sulfonylurea exposure and the risk of prolonged hypoglycaemia.

What you should do

Consider an alternative antibiotic or temporarily reduce the glibenclamide dose. Increase glucose monitoring during treatment and for several days after trimethoprim is stopped.

Key facts

Severity

Moderate — caution required

Mechanism

Trimethoprim inhibits CYP2C9-mediated metabolism of glibenclamide, increasing sulfonylurea exposure and the risk of prol...

Action

Consider an alternative antibiotic or temporarily reduce the glibenclamide dose. Increase glucose monitoring during trea...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Glibenclamide and Trimethoprim together?

With caution. Consider an alternative antibiotic or temporarily reduce the glibenclamide dose. Increase glucose monitoring during treatment and for several days after trimethoprim is stopped.

What is the severity of this interaction?

The interaction between Glibenclamide and Trimethoprim is classified as Moderate — caution required. Trimethoprim inhibits CYP2C9-mediated metabolism of glibenclamide, increasing sulfonylurea exposure and the risk of prolonged hypoglycaemia.

What should I do if I'm prescribed both?

Consider an alternative antibiotic or temporarily reduce the glibenclamide dose. Increase glucose monitoring during treatment and for several days after trimethoprim is stopped. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.