Gliclazide and Miconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Gliclazide and Miconazole unless specifically directed by your doctor.
How Gliclazide interacts with Miconazole
Miconazole inhibits CYP2C9 metabolism of sulfonylureas such as gliclazide. Increased sulfonylurea exposure can cause severe and prolonged hypoglycemia.
What you should do
Avoid systemic or oral-gel miconazole with gliclazide. Use an alternative antifungal and advise glucose monitoring if exposure has occurred.
Key facts
Severity
Major — avoid combination
Mechanism
Miconazole inhibits CYP2C9 metabolism of sulfonylureas such as gliclazide. Increased sulfonylurea exposure can cause sev...
Action
Avoid systemic or oral-gel miconazole with gliclazide. Use an alternative antifungal and advise glucose monitoring if ex...
Frequently asked questions
Can I take Gliclazide and Miconazole together?
No — this combination should generally be avoided. Avoid systemic or oral-gel miconazole with gliclazide. Use an alternative antifungal and advise glucose monitoring if exposure has occurred.
What is the severity of this interaction?
The interaction between Gliclazide and Miconazole is classified as Major — avoid combination. Miconazole inhibits CYP2C9 metabolism of sulfonylureas such as gliclazide. Increased sulfonylurea exposure can cause severe and prolonged hypoglycemia.
What should I do if I'm prescribed both?
Avoid systemic or oral-gel miconazole with gliclazide. Use an alternative antifungal and advise glucose monitoring if exposure has occurred. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.