Gliclazide and Sulfamethoxazole: Drug Interaction Guide

Quick answer: This combination requires caution. Gliclazide and Sulfamethoxazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Gliclazide interacts with Sulfamethoxazole

Sulfamethoxazole can inhibit CYP2C9 and may displace sulfonylureas from protein binding. Gliclazide exposure and hypoglycaemic effect may increase.

What you should do

Use an alternative antibiotic when suitable. If combined, increase glucose monitoring and consider temporary sulfonylurea dose reduction.

Key facts

Severity

Moderate — caution required

Mechanism

Sulfamethoxazole can inhibit CYP2C9 and may displace sulfonylureas from protein binding. Gliclazide exposure and hypogly...

Action

Use an alternative antibiotic when suitable. If combined, increase glucose monitoring and consider temporary sulfonylure...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Gliclazide and Sulfamethoxazole together?

With caution. Use an alternative antibiotic when suitable. If combined, increase glucose monitoring and consider temporary sulfonylurea dose reduction.

What is the severity of this interaction?

The interaction between Gliclazide and Sulfamethoxazole is classified as Moderate — caution required. Sulfamethoxazole can inhibit CYP2C9 and may displace sulfonylureas from protein binding. Gliclazide exposure and hypoglycaemic effect may increase.

What should I do if I'm prescribed both?

Use an alternative antibiotic when suitable. If combined, increase glucose monitoring and consider temporary sulfonylurea dose reduction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.