Gliclazide and Trimethoprim: Drug Interaction Guide

Quick answer: This combination requires caution. Gliclazide and Trimethoprim can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Gliclazide interacts with Trimethoprim

Trimethoprim may inhibit renal tubular secretion and alter sulfonylurea exposure, increasing hypoglycaemia risk in susceptible patients.

What you should do

Monitor blood glucose closely during therapy and consider temporary sulfonylurea dose reduction.

Key facts

Severity

Moderate — caution required

Mechanism

Trimethoprim may inhibit renal tubular secretion and alter sulfonylurea exposure, increasing hypoglycaemia risk in susce...

Action

Monitor blood glucose closely during therapy and consider temporary sulfonylurea dose reduction.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Gliclazide and Trimethoprim together?

With caution. Monitor blood glucose closely during therapy and consider temporary sulfonylurea dose reduction.

What is the severity of this interaction?

The interaction between Gliclazide and Trimethoprim is classified as Moderate — caution required. Trimethoprim may inhibit renal tubular secretion and alter sulfonylurea exposure, increasing hypoglycaemia risk in susceptible patients.

What should I do if I'm prescribed both?

Monitor blood glucose closely during therapy and consider temporary sulfonylurea dose reduction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.