Indomethacin and Lithium: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Indomethacin and Lithium unless specifically directed by your doctor.
How Indomethacin interacts with Lithium
NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar dilation and increasing proximal tubular reabsorption of lithium by up to 60%.
What you should do
Avoid combination. If unavoidable, reduce lithium dose by 50%, monitor levels within 5-7 days, and watch for toxicity signs.
Key facts
Severity
Major — avoid combination
Mechanism
NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar dilation and increasing proximal tubular reab...
Action
Avoid combination. If unavoidable, reduce lithium dose by 50%, monitor levels within 5-7 days, and watch for toxicity si...
Frequently asked questions
Can I take Indomethacin and Lithium together?
No — this combination should generally be avoided. Avoid combination. If unavoidable, reduce lithium dose by 50%, monitor levels within 5-7 days, and watch for toxicity signs.
What is the severity of this interaction?
The interaction between Indomethacin and Lithium is classified as Major — avoid combination. NSAIDs inhibit renal prostaglandin synthesis, reducing afferent arteriolar dilation and increasing proximal tubular reabsorption of lithium by up to 60%.
What should I do if I'm prescribed both?
Avoid combination. If unavoidable, reduce lithium dose by 50%, monitor levels within 5-7 days, and watch for toxicity signs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.