Indomethacin and Ramipril: Drug Interaction Guide
Quick answer: This combination requires caution. Indomethacin and Ramipril can be used together with adjustments and monitoring.
How Indomethacin interacts with Ramipril
NSAIDs inhibit renal prostaglandin synthesis, attenuating ACE inhibitor-induced vasodilation and natriuresis and increasing risk of acute kidney injury and hyperkalaemia.
What you should do
Avoid chronic NSAID use with ACE inhibitors; if needed short-term, use the lowest dose for shortest duration, ensure hydration, and check renal function and potassium within a week.
Key facts
Severity
Moderate — caution required
Mechanism
NSAIDs inhibit renal prostaglandin synthesis, attenuating ACE inhibitor-induced vasodilation and natriuresis and increas...
Action
Avoid chronic NSAID use with ACE inhibitors; if needed short-term, use the lowest dose for shortest duration, ensure hyd...
Frequently asked questions
Can I take Indomethacin and Ramipril together?
With caution. Avoid chronic NSAID use with ACE inhibitors; if needed short-term, use the lowest dose for shortest duration, ensure hydration, and check renal function and potassium within a week.
What is the severity of this interaction?
The interaction between Indomethacin and Ramipril is classified as Moderate — caution required. NSAIDs inhibit renal prostaglandin synthesis, attenuating ACE inhibitor-induced vasodilation and natriuresis and increasing risk of acute kidney injury and hyperkalaemia.
What should I do if I'm prescribed both?
Avoid chronic NSAID use with ACE inhibitors; if needed short-term, use the lowest dose for shortest duration, ensure hydration, and check renal function and potassium within a week. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.