Itraconazole and Quetiapine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Itraconazole and Quetiapine unless specifically directed by your doctor.
How Itraconazole interacts with Quetiapine
Itraconazole is a strong CYP3A4 inhibitor that markedly reduces quetiapine clearance, increasing AUC up to sixfold and the risk of sedation, hypotension, and QT prolongation.
What you should do
Reduce quetiapine to one-sixth of the usual dose during itraconazole therapy, or switch antifungal/antipsychotic class.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole is a strong CYP3A4 inhibitor that markedly reduces quetiapine clearance, increasing AUC up to sixfold and t...
Action
Reduce quetiapine to one-sixth of the usual dose during itraconazole therapy, or switch antifungal/antipsychotic class.
Frequently asked questions
Can I take Itraconazole and Quetiapine together?
No — this combination should generally be avoided. Reduce quetiapine to one-sixth of the usual dose during itraconazole therapy, or switch antifungal/antipsychotic class.
What is the severity of this interaction?
The interaction between Itraconazole and Quetiapine is classified as Major — avoid combination. Itraconazole is a strong CYP3A4 inhibitor that markedly reduces quetiapine clearance, increasing AUC up to sixfold and the risk of sedation, hypotension, and QT prolongation.
What should I do if I'm prescribed both?
Reduce quetiapine to one-sixth of the usual dose during itraconazole therapy, or switch antifungal/antipsychotic class. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.