Ketoconazole and Lurasidone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ketoconazole and Lurasidone unless specifically directed by your doctor.
How Ketoconazole interacts with Lurasidone
Ketoconazole is a strong CYP3A4 inhibitor and lurasidone is primarily metabolized by CYP3A4. Co-administration can greatly increase lurasidone exposure and adverse effects.
What you should do
Do not use lurasidone with strong CYP3A4 inhibitors such as ketoconazole. Choose an alternative antifungal or antipsychotic.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole is a strong CYP3A4 inhibitor and lurasidone is primarily metabolized by CYP3A4. Co-administration can great...
Action
Do not use lurasidone with strong CYP3A4 inhibitors such as ketoconazole. Choose an alternative antifungal or antipsycho...
Frequently asked questions
Can I take Ketoconazole and Lurasidone together?
No — this combination should generally be avoided. Do not use lurasidone with strong CYP3A4 inhibitors such as ketoconazole. Choose an alternative antifungal or antipsychotic.
What is the severity of this interaction?
The interaction between Ketoconazole and Lurasidone is classified as Major — avoid combination. Ketoconazole is a strong CYP3A4 inhibitor and lurasidone is primarily metabolized by CYP3A4. Co-administration can greatly increase lurasidone exposure and adverse effects.
What should I do if I'm prescribed both?
Do not use lurasidone with strong CYP3A4 inhibitors such as ketoconazole. Choose an alternative antifungal or antipsychotic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.