Ketoconazole and Palbociclib: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ketoconazole and Palbociclib unless specifically directed by your doctor.
How Ketoconazole interacts with Palbociclib
Ketoconazole strongly inhibits CYP3A4, substantially increasing palbociclib exposure and the risk of severe neutropenia and other toxicities.
What you should do
Avoid concomitant use and select an alternative antifungal. If unavoidable, reduce palbociclib according to its prescribing information and monitor blood counts closely.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole strongly inhibits CYP3A4, substantially increasing palbociclib exposure and the risk of severe neutropenia ...
Action
Avoid concomitant use and select an alternative antifungal. If unavoidable, reduce palbociclib according to its prescrib...
Frequently asked questions
Can I take Ketoconazole and Palbociclib together?
No — this combination should generally be avoided. Avoid concomitant use and select an alternative antifungal. If unavoidable, reduce palbociclib according to its prescribing information and monitor blood counts closely.
What is the severity of this interaction?
The interaction between Ketoconazole and Palbociclib is classified as Major — avoid combination. Ketoconazole strongly inhibits CYP3A4, substantially increasing palbociclib exposure and the risk of severe neutropenia and other toxicities.
What should I do if I'm prescribed both?
Avoid concomitant use and select an alternative antifungal. If unavoidable, reduce palbociclib according to its prescribing information and monitor blood counts closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.