Ketorolac and Lithium: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ketorolac and Lithium unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ketorolac interacts with Lithium

NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and lithium clearance, with ketorolac producing rapid and marked elevations in lithium concentration.

What you should do

Avoid this combination. Use paracetamol or opioids for analgesia in patients on lithium; if NSAID essential, monitor lithium levels within 3-5 days.

Key facts

Severity

Major — avoid combination

Mechanism

NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and lithium clearance, with ketorolac producing ...

Action

Avoid this combination. Use paracetamol or opioids for analgesia in patients on lithium; if NSAID essential, monitor lit...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ketorolac and Lithium together?

No — this combination should generally be avoided. Avoid this combination. Use paracetamol or opioids for analgesia in patients on lithium; if NSAID essential, monitor lithium levels within 3-5 days.

What is the severity of this interaction?

The interaction between Ketorolac and Lithium is classified as Major — avoid combination. NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and lithium clearance, with ketorolac producing rapid and marked elevations in lithium concentration.

What should I do if I'm prescribed both?

Avoid this combination. Use paracetamol or opioids for analgesia in patients on lithium; if NSAID essential, monitor lithium levels within 3-5 days. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.