Ketorolac and Warfarin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ketorolac and Warfarin unless specifically directed by your doctor.
How Ketorolac interacts with Warfarin
Ketorolac inhibits platelet function and damages gastrointestinal mucosa, while warfarin impairs coagulation through vitamin K antagonism. The combination substantially increases serious bleeding risk.
What you should do
Avoid coadministration. Use alternative analgesia and monitor closely for bleeding if inadvertent combined exposure occurs.
Key facts
Severity
Major — avoid combination
Mechanism
Ketorolac inhibits platelet function and damages gastrointestinal mucosa, while warfarin impairs coagulation through vit...
Action
Avoid coadministration. Use alternative analgesia and monitor closely for bleeding if inadvertent combined exposure occu...
Frequently asked questions
Can I take Ketorolac and Warfarin together?
No — this combination should generally be avoided. Avoid coadministration. Use alternative analgesia and monitor closely for bleeding if inadvertent combined exposure occurs.
What is the severity of this interaction?
The interaction between Ketorolac and Warfarin is classified as Major — avoid combination. Ketorolac inhibits platelet function and damages gastrointestinal mucosa, while warfarin impairs coagulation through vitamin K antagonism. The combination substantially increases serious bleeding risk.
What should I do if I'm prescribed both?
Avoid coadministration. Use alternative analgesia and monitor closely for bleeding if inadvertent combined exposure occurs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.