Leflunomide and Methotrexate: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Leflunomide and Methotrexate unless specifically directed by your doctor.
How Leflunomide interacts with Methotrexate
Both drugs are immunosuppressive disease-modifying antirheumatic agents with overlapping hepatotoxic and myelosuppressive effects. Additive toxicity can cause liver injury and bone marrow suppression.
What you should do
Avoid unless specialist-supervised. Monitor liver enzymes, full blood count, and infection risk closely if combination therapy is used.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs are immunosuppressive disease-modifying antirheumatic agents with overlapping hepatotoxic and myelosuppressiv...
Action
Avoid unless specialist-supervised. Monitor liver enzymes, full blood count, and infection risk closely if combination t...
Frequently asked questions
Can I take Leflunomide and Methotrexate together?
No — this combination should generally be avoided. Avoid unless specialist-supervised. Monitor liver enzymes, full blood count, and infection risk closely if combination therapy is used.
What is the severity of this interaction?
The interaction between Leflunomide and Methotrexate is classified as Major — avoid combination. Both drugs are immunosuppressive disease-modifying antirheumatic agents with overlapping hepatotoxic and myelosuppressive effects. Additive toxicity can cause liver injury and bone marrow suppression.
What should I do if I'm prescribed both?
Avoid unless specialist-supervised. Monitor liver enzymes, full blood count, and infection risk closely if combination therapy is used. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.