Lithium and Perindopril: Drug Interaction Guide

Quick answer: This combination requires caution. Lithium and Perindopril can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Lithium interacts with Perindopril

ACE inhibitors can reduce renal lithium clearance through effects on glomerular filtration and sodium handling. Lithium concentrations may rise, causing tremor, confusion, ataxia, or renal toxicity.

What you should do

Check lithium concentration and renal function after starting, stopping, or changing perindopril. Reduce lithium dose if concentrations rise or toxicity develops.

Key facts

Severity

Moderate — caution required

Mechanism

ACE inhibitors can reduce renal lithium clearance through effects on glomerular filtration and sodium handling. Lithium ...

Action

Check lithium concentration and renal function after starting, stopping, or changing perindopril. Reduce lithium dose if...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lithium and Perindopril together?

With caution. Check lithium concentration and renal function after starting, stopping, or changing perindopril. Reduce lithium dose if concentrations rise or toxicity develops.

What is the severity of this interaction?

The interaction between Lithium and Perindopril is classified as Moderate — caution required. ACE inhibitors can reduce renal lithium clearance through effects on glomerular filtration and sodium handling. Lithium concentrations may rise, causing tremor, confusion, ataxia, or renal toxicity.

What should I do if I'm prescribed both?

Check lithium concentration and renal function after starting, stopping, or changing perindopril. Reduce lithium dose if concentrations rise or toxicity develops. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.