Maois and Pethidine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Maois and Pethidine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Maois interacts with Pethidine

Pethidine inhibits serotonin reuptake; combined with MAOIs the resulting excess serotonin and noradrenaline can cause severe serotonin syndrome, hypertension, and hyperthermia.

What you should do

Contraindicated; do not use pethidine within 14 days of an MAOI. Use morphine or fentanyl as safer opioid alternatives.

Key facts

Severity

Major — avoid combination

Mechanism

Pethidine inhibits serotonin reuptake; combined with MAOIs the resulting excess serotonin and noradrenaline can cause se...

Action

Contraindicated; do not use pethidine within 14 days of an MAOI. Use morphine or fentanyl as safer opioid alternatives.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Maois and Pethidine together?

No — this combination should generally be avoided. Contraindicated; do not use pethidine within 14 days of an MAOI. Use morphine or fentanyl as safer opioid alternatives.

What is the severity of this interaction?

The interaction between Maois and Pethidine is classified as Major — avoid combination. Pethidine inhibits serotonin reuptake; combined with MAOIs the resulting excess serotonin and noradrenaline can cause severe serotonin syndrome, hypertension, and hyperthermia.

What should I do if I'm prescribed both?

Contraindicated; do not use pethidine within 14 days of an MAOI. Use morphine or fentanyl as safer opioid alternatives. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.